课题组简介: 肖波课题组主要从分子、细胞和小鼠模型等方面阐明神经系统发育与再生机制，致力于研究神经/精神疾病发病过程中神经元-胶质细胞的相互作用及其分子调控网络。 进一步拓展研究小胶质细胞功能调控及其在神经环路形成与维持过程中的重要作用。研究团队近年来已在Developmental Cell、Nature Neuroscience、Neuron、Journal of Neuroscience等国际权威学术刊物发表多篇高水平学术论文。实验室现拟招聘博士后研究人员若干名，欢迎感兴趣的科研人员加盟。

岗位要求：有生物学、医学或相关专业博士学历；能利用分子生物学、生物化学、遗传学、转基因动物等手段开展相对独立研究。工作认真负责，勤奋踏实，态度严谨；有良好的沟通交流能力和英文阅读及写作基础。

岗位目标与职责：相对独立地完成课题研究，在相应领域达到国际领先的科研能力，发表高水平学术论文。协助指导博硕士研究生并协助管理实验室。

聘期待遇：  

1. 年薪27万起，其中深圳市财政生活补贴12万元/年（免税）。特别优秀者可以申请校长卓越博士后，年薪35万元以上；
2. 享受医疗保险、养老保险、工伤保险等基本社会保险；
3. 享受过节费、餐补、计划生育奖励、免费体检等福利待遇；
4. 提供良好的科研与办公条件和校内住宿（或公租房补贴），学校为每位博士后提供两年2.5万元的学术交流资助；
5. 可申请深圳户口，解决子女入托问题。

发展前景：

1. 出站后业绩突出者可推荐留任南方科技大学（如研究教授序列），其它深圳科研企业单位，或国外合作单位继续深造；
2. 协助申请国家自然科学基金，广东省及深圳市相应基础研究和专业创新项目；
3. 出站留深工作满三年，符合深圳市后备级条件的可获80-100万元的住房补贴和可申请30万元RMB科研启动经费。
4. 海外博士或具有一年以上留学经历留深工作可申请深圳市孔雀计划160-200万住房补贴；200-500万科研启动经费。

联系方式：有意向者请将简历及两名以上推荐人的联系方式发至：neuroscience_sustc@163.com

邮件标题请注明：应聘博士后+姓名。本招聘长期有效，直到岗位招满为止

Postdoc Positions in Plant Cell Biology & Molecular Engineering
Positions are available at the research group of Peter Pimpl at the Department of Biology at
SUSTech, Shenzhen. Positions are available for 2 years from 1 August 2017

The focus of the research team is the analysis of the molecular mechanisms of protein sorting and transport in the endomembrane system of plants. We analyze protein targeting and membrane trafficking and organelle biogenesis, thereby aiming at the development of strategies to engineer new functionalized cellular compartments. To reach this aim, we pioneer the use of nanobody fusion proteins, the next generation molecular tools, for the non‐invasive analysis and manipulation of cellular functions (Kunzl et al., 2016, Nature Plants 2, 16017).

Position Description:
The postdocs will develop strategies to trace protein transport, to map transport routes in the endomembrane system and to specifically target transport vesicles.
The postdocs will design and generate nanobody/epitope‐tagged fusion proteins, perform locationspecific interaction analysis by combining methods from molecular biology, biochemistry with stateof‐the‐art live‐cell imaging and ultrastructural analysis.
The candidate will be offered an attractive salary and benefits package that will be dependent on qualification and experience.

Position Requirements:
Candidates must hold a Ph.D. or equivalent degree in biology, bioengineering or another related field
Candidates should have a strong background in cell biology and must possess very good language proficiency in English speaking and writing.

Inquiries & Application:
Please send your full application in English language (motivation letter, full curriculum vitae with two recommendation letters) as one combined pdf file to: pimpl@sustc.edu.cn
Applications will be accepted until the positions are filled.

课题组简介: Our long-term research interest concerns the molecular mechanisms that regulate the formation and maintenance of neuronal circuitry，with the focus on the role of mTOR signaling in the regulation of neuron-glia interactions in health and disease. While continuing our study of mTOR activation that regulates neuron-oligodendrocyte interactions, we will extend our work to understand its role in microglia and the impact of dys-regulated microglia functions on the formation and maintenance of neuronal circuitry. To gain a better understanding of our research interests, please read our recent publications in Developmental Cell, Nature Neuroscience, Neuron, and the Journal of Neuroscience.  

岗位要求：具有生物学、医学或相关专业博士学历；能够利用分子生物学、生物化学、遗传学、转基因动物等手段进行相对独立的研究。勤奋，认真，负责的工作态度;良好的沟通能力和写作水平。

岗位目标与职责：相对独立地完成相关方向的课题研究，在相应领域达到国际领先的科研能力，发表高水平学术论文。协助指导低年级研究生的训练与培养。

聘期待遇：      

1. 年薪27万起，其中深圳市财政生活补贴12万元/年（免税）。特别优秀者可以申请校长卓越博士后，年薪35万元以上；
2.  享受医疗保险、养老保险、工伤保险等基本社会保险；
3.  享受过节费、餐补、计划生育奖励、免费体检等福利待遇；
4. 提供良好的科研与办公条件和校内住宿（或公租房补贴），学校为每位博士后提供两年2.5万元的学术交流资助；
5. 可以申请深圳户口，解决子女入托问题。

发展前景：

1. 出站后业绩突出者可推荐留任南方科技大学（如研究教授序列），其它深圳科研企业单位，或国外合作单位继续深造；
2. 协助申请国家自然科学基金，广东省以及深圳市相应基础研究和专业创新项目；
3. 出站留深工作满三年，符合深圳市后备级条件的可获80-100万元的住房补贴和可申请30万元RMB科研启动经费。
4. 海外博士或具有一年以上留学经历留深工作可申请深圳市孔雀计划160-200万住房补贴；200-500万科研启动经费。

联系方式：有意向者请将简历及两名推荐人的联系方式发至：neuroscience_sustc@163.com

邮件标题请注明：应聘博士后+姓名。本招聘长期有效，直到岗位招满为止。

课题组简介：肖波课题组主要通过基因敲除等手段，建立神经发育, 损伤与退行性疾病动物模型，并通过分子，细胞等生物学手段研究神经系统（特别是髓鞘系统）发育与再生的机制。研究团队近年已在Developmental Cell, Nature Neuroscience, The Journal of Neuroscience 等国际主流刊物发表多篇高水平学术论文。现拟招聘课题相关研究助理，欢迎有志之士加入。

招聘岗位：研究助理（Research Assistant）

【岗位要求】

• 获得生物学领域相关专业学士或硕士学位；
• 对神经生物学有研究热情，能吃苦耐劳，有上进心和团队合作精神，恪守科研道德；
• 掌握分子生物学，细胞生物学等常规实验技能，有神经细胞培养经验者优先；
• 思维清晰，口头表达能力强，能独立阅读英文文献；

【岗位职责和目标】

• 与实验室其他研究助理共同承担一部分实验室公共事务；
• 协助博士研究生及博士后研究人员完成相关研究工作；

【岗位待遇】

• 薪资6000-7000，享有五险一金，及学校其他教师职工福利待遇，可申请学校统一宿舍；
• 有机会就读我校博士研究生，及到国外一流学校交流访问；

【申请材料】

1）个人简历（含学习、工作和科研的经历）；

2）主要科研成果（如论文论著、成果证书或奖励）清单；

3）其他可以证明工作能力的材料；

【联系方式】

将应聘者申请材料发送到：yuzongyan00@163.com

工作地点:深圳

薪金:年薪10万以上

学历和研究方向:生物信息、分子生物

招聘岗位:科研助理或访问学生

联系方式:zhaijx@sustc.edu.cn

翟继先介绍: http://www.sustc.edu.cn/biology_04/f/Zhai_jixian

感兴趣的同学请将个人简历和代表论文发送到  zhaijx@sustc.edu.cn

研究方向 （生物信息学和分子生物学相结合）：

表观遗传组学，染色体高级结构，DNA甲基化，non-coding RNA

应聘条件：

1）在分子生物学或生物信息学相关专业领域已毕业或即将毕业的本科，硕士，或博士在读生；

2）撰写的研究论文已在高水平国际学术期刊发表或接收发表者优先考虑；

3）有NGS文库构建或测序数据分析经验优先考虑；

4）有植物相关研究经历优先考虑。

聘期待遇以发展前景：

基本工资7000-10000元/月，13薪，另外每年有17840元的福利费（餐补，高温补贴，过节费和计生奖等）。除此以外，学校承担五险一金和支付住房公积金。

个人简介：

翟继先05年本科毕业于中国科学技术大学，08年在中科院遗传与发育生物学研究所曹晓风院士指导下获得遗传学硕士，13年在Blake Meyers教授指导下获得美国特拉华大学博士学位（同期还完成了生物信息和统计学的两个硕士），之后加入加州大学洛杉矶分校美国科学院院士Steve Jacobsen课题组从事博士后研究。16年加入南方科技大学生物系。目前已经在主流期刊上发表了46篇文章，其中第一作者（或共一）8篇，包括Cell, PNAS, Genes&Development, The Plant Cell, PLoS Genetics等顶尖期刊。

代表文章：

At SUSTech

1. Kuo HY, Jacobsen E, Long Y, Chen X, Zhai J# (2017) Characteristics and processing of Pol IV transcripts in Arabidopsis. Journal of Genetics and Genomics in press. (#corresponding author)
2. Nan GL, Zhai J, Arikit S, Morrow D, Fernandes J, Mai L, Nguyen N, Meyers BC, Walbot V (2016), a master basic helix-loop-helix factor, regulates the specification and development of tapetum in maize Development dev.140673
3. Ausin I, Feng S, Yu C, Liu W, Kuo HY, Jacobsen EL, Zhai J, Gallego-Bartolome J, Wang L, Egertsdotter U, Street NR, Jacobsen SE, Wang H (2016) DNA methylome of the 20-gigabase Norway spruce genome. PNAS 113(50):E8106-13

At previous institutions

First author research papers:

4. Zhai J*, Bischof S*, Wang H, Feng S, Lee T, Teng C, Chen X, Park SY, Liu L, Gallego-Bartolome J, Liu W, Henderson I, Meyers BC, Ausin I, Jacobsen SE (2015) A ‘One precursor, One siRNA’ model for Pol IV-dependent siRNA Biogenesis. Cell 163, 445–455 (*co-first author)
5. Zhai J*, Zhang H*, Arikit S, Huang K, Nan G, Walbot V, Meyers BC (2015) Spatiotemporal and cell-type dependent phasiRNA biogenesis in maize male reproduction. PNAS 112(10): 3146-51 (*co-first author)
6. Zhai J, Zhao Y, Simon SA, Huang S, Petsch K, Arikit S, Pillay L, Ji L, et al. (2013) Plant microRNAs display differential 3’-truncation and tailing, modifications which are ARGONAUTE1-dependent and conserved across species. The Plant Cell 25(7):2417-28
7. Zhai J, Jeong D-H, Paoli ED, Park S, Rosen BD, Li Y, González AJ, Yan Z, et al. (2011) MicroRNAs as master regulators of the plant NB-LRR defense gene family via the production of phased, trans-acting siRNAs. Genes & Development 25(23):2540-53.
8. Zhai J, Liu J, Liu B, Li P, Meyers BC, Chen X, Cao X. (2008) Small RNA-directed epigenetic natural variation in Arabidopsis thaliana. PLoS Genetics 4, e1000056.
9. Song X*, Li P*, Zhai J*, Zhou M, Ma L, Liu B, Jeong DH, Cao S, Cui X et al. (2011) Roles of DCL4 and DCL3b in rice phased small RNA biogenesis. The Plant Journal 69, 462-474. (*co-first author)
10. Zhai J, Arikit S, Simon SA, Kingham B, Meyers BC (2013) Construction of Parallel Analysis of RNA End (PARE) Library for Illumina Hi-Seq sequencing. Methods S1046-2023(13)00237-5
11. Zhai J and Meyers BC (2013). Deep Sequencing from hen1 Mutants to Identify Small RNA 3' Modifications. Cold Spring Harb Symp Quant Biol 1943-4456

Co-authored papers (in reverse-chronological order):

12. Yu Y, Ji L, Le B, Zhai J, Chen J, Luscher E, Gao L, Liu C, Cao X, Mo B, Ma J, Meyers BC, Chen X (2017) ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biology, in press.
13. Groth M, Moissiard G, Wirtz M, Wang H, GarciaSalinas G, Ramos-Parra PA, Bischof S, Feng S, Cokus SJ, John A, Smith DC, Zhai J, Hale CJ, Long JA, Hell R, Garza RID, Jacobsen SE (2016) MTHFD1 controls DNA methylation in Arabidopsis. Nature Communication 2016 Jun 13;7:11640
14. Wang H, Beyene G, Zhai J, Feng S, Fahlgren N, Taylor N, Bart R, Carrington JC, Jacobsen SE, Ausin I (2015) CG gene body DNA methylation changes and evolution of duplicated genes in cassava. PNAS 112(44):13729-34
15. Yan Z, Hossain MS, Valdés-López O, Hoang NT, Zhai J, Wang J, Libault M, Joshi T, Brechenmacher L, Findley S, Qiu L, Sherrier DJ, Meyers BC, Xu D, Stacey G (2015) Identification and functional characterization of soybean root hair microRNAs expressed in response to Bradyrhizobium japonicum infection. Plant Biotechnology Journal 10.1111/pbi.12387
16. Tu B, Xu C, Liu L, Zhai J, Li S, Lopez MA, Zhao Y, Yu Y, Ren G, Yu B, Li S, Meyers BC, Mo B, Chen X (2015) Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis. PLoS Genetics 11(4): e1005119
17. Yan Z, Hossain MS, Arikit S, Valdé O, Zhai J, Wang J, Libault M, Ji T, Qiu L, Meyers BC, Stacey G (2015) Identification of MicroRNAs and their mRNA targets during soybean nodule development: Functional analysis of the role of miR393* in soybean nodulation. New Phytologist 10.1111/nph.13365
18. Zhao M, Cai C, Zhai J, Lin F, Li L, Shreve J, Thimmapuram J, Hughes TJ, Meyers BC, Ma J (2015) Coordination of MicroRNAs, PhasiRNAs, and NB-LRR Genes in Immune Responses: Insights from Analyses of Soybean Rps Gene Near-Isogenic Lines. The Plant Genome 10.3835
19. Cantó-Pastor A, Mollá-Morales A, Ernst E, Dahl W, Zhai J, Yan Y, Meyers BC, Shanklin J, Martienssen RA (2015) Efficient transformation and artificial miRNA gene silencing in Lemna minor. Plant Biology 10.1111/plb.12215
20. Arikit S, Xia R, Kakrana A, Huang K, Zhai J, Yan Z, Valdés-López O, Prince S, Musket TA, Nguyen HT, Stacey G, Meyers BC (2014) An atlas of soybean small RNAs demonstrates regulation by phased siRNAs of hundreds of coding genes. The Plant Cell 26: 4584-4601
21. Feng S, Cokus SJ, Schubert V, Zhai J, Pellegrini M, Jacobsen SE (2014) Genome-wide Hi-C analyses in wild type and mutants reveal high-resolution chromatin interactions in Arabidopsis. Molecular Cell 55(5):694-707
22. Wong J, Gao L, Yang Y, Zhai J, Arikit S, Yu Y, Duan S, Xiong Q, Yan J, Li S, Liu R, Wang Y, Tang G, Meyers BC, Chen X, Ma W (2014) Roles of Small RNAs in Soybean Defense against Phytophthora sojae Infection. The Plant Journal 10.1111/tpj.12590
23. Creasey KM, Zhai J, Borges F, Van EF, Meyers BC, Martienssen RA (2014) miRNAs trigger widespread epigenetically-activated siRNAs from transposons in Arabidopsis. Nature 508 (7496):411-5
24. Wei L, Gu L, Song X, Cui X, Lua Z, Zhou M, Wang L, Hu F, Zhai J, Meyers BC, Cao X (2014) Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice. PNAS 111(10):3877-82
25. Schapire A, Bologna NG, Moro B, Zhai J, Meyers BC, Palatnik JF (2013) Construction of Specific Parallel Amplification of RNA Ends (SPARE) libraries for the systematic identification of plant microRNA processing intermediates. Methods doi:10.1016/j.ymeth.2013.08.032
26. Jeong DH, Schmidt SA, Rymarquis LA, Park S, Ganssmann M, German MA, Accerbi M, Zhai J, Paoli ED, Fahlgren N, Fox SE, Garvin DF, Mockler TC, Carrington JC, Meyers BC, and Green PJ (2013) Parallel Analysis of RNA Ends enhances global investigation of microRNAs and target RNAs of Brachypodium distachyon. Genome Biology 14(12):R145
27. Amborella Genome Project. (2013) The Amborella Genome and the Evolution of Flowering Plants. Science 342(6165):1241089
28. Jeong DH, Thatcher SR, Brown RS, Zhai J, Park S, Meyers BC, Green PJ (2013) Comprehensive investigation of miRNAs enhanced by analysis of sequence variants, expression patterns, AGO loading and target cleavage. Plant Physiology 162(3):1225
29. Raman V, Simon SA, Romag A, Demirci F, Mathioni SM, Zhai J, Meyers BC, Donofrio NM (2013) Physiological stressors and invasive plant infections alter the small RNA transcriptome of the rice blast fungus Magnaporthe oryzae. BMC Genomics 14:326
30. Bologna NG, Schapire AL, Zhai J, Chorostecki U, Boisbouvier J, Meyers BC, Palatnik J (2013) Multiple RNA recognition patterns during microRNA biogenesis in plants. Genome Research (10):1675-89
31. Arikit S, Zhai J, Meyers BC (2013) Biogenesis and function of rice small RNAs from non-coding RNA precursors. Current Opinion in Plant Biology 16(2):170-9.
32. Lee TF, Gurazada SG, Zhai J, Li S, Simon SA, Matzke MA, Chen X, Meyers BC (2012) RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. Epigenetics 7(7):781-95
33. Zhao Y, Yu Y, Zhai J, Ramachandran V, Dinh T, Meyers BC, Mo B, Chen X (2012) HESO1, a nucleotidyl transferase in Arabidopsis, uridylates unmethylated miRNAs and siRNAs to trigger their degradation. Current Biology 22(8):689-94
34. The_International_Medicago_Initiative (2011) The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature 480, 520-524
35. Jeong D-H, Park S, Zhai J, Gurazada SGR, Paoli ED, Meyers BC, Green PJ. (2011) Massive analysis of rice small RNAs: Mechanistic implications of regulated miRNAs and variants for differential target RNA cleavage. The Plant Cell 23(12):4185-207.
36. Yu B, Bi L, Zhai J, Agarwal M, Li S, Wu Q, Ding SW, Meyers BC, Vaucheret H, Chen X. (2010) siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis. Nucleic Acids Research 38(17):5844-5850.
37. The International Brachypodium Initiative. (2010) Genome sequencing and analysis of the model grass Brachypodium distachyon. Nature 463(7282):763-768.
38. Meyers BC, Simon SA, Zhai J. (2010) MicroRNA processing: battle of the bulge. Current Biology 20(2):R68-70. (review)
39. Lee TF, Zhai J, Meyers BC. (2010) Conservation and divergence in eukaryotic DNA methylation. PNAS 107(20):9027-9028. (review)
40. Simon SA, Zhai J, Nandety RS, McCormick KP, Zeng J, Mejia D, Meyers BC. (2009) Short-read sequencing technologies for transcriptional analyses. Annual Review Plant Biology 60:305-333. (review)
41. Park W, Zhai J, Lee JY. (2009) Highly efficient gene silencing using perfect complementary artificial miRNA targeting AP1 or heteromeric artificial miRNA targeting AP1 and CAL genes. Plant Cell Rep 28(3):469-480.
42. De Paoli E, Dorantes-Acosta A, Zhai J, Accerbi M, Jeong DH, Park S, Meyers BC, Jorgensen RA, Green PJ. (2009) Distinct extremely abundant siRNAs associated with cosuppression in petunia. RNA 15(11):1965-1970.
43. Simon SA, Zhai J, Zeng J, Meyers BC. (2008) The cornucopia of small RNAs in plant genomes. Rice 1(1):52-62. (review)
44. Pei Y, Niu L, Lu F, Liu C, Zhai J, Kong X, Cao X. (2007) Mutations in the Type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis. Plant Physiology 144, 1913-1923.
45. Ding Y, Wang X, Su L, Zhai J, Cao S, Zhang D, Liu C, Bi Y, Qian Q, Cheng Z, et al. (2007) SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. The Plant Cell 19, 9-22.
46. Xia R, Wang J, Liu C, Wang Y, Zhai J, Liu J, Hong X, Cao X, Zhu JK, Gong Z. (2006) ROR1/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis. The Plant Cell 18, 85-103. 1(1):52-62.

翟继先介绍: http://www.sustc.edu.cn/biology_04/f/Zhai_jixian

感兴趣的同学请将个人简历和代表论文发送到  zhaijx@sustc.edu.cn

研究方向 （高通量测序，生物信息分析和分子生物学实验相结合）：

表观遗传组学，染色体高级结构，DNA甲基化，non-coding RNA

应聘条件：

1）在分子生物学或生物信息学相关专业领域已毕业或即将毕业的博士，有植物研究经历优先；

2）撰写的研究论文已在高水平国际学术期刊发表或接收发表者优先；

3）有NGS文库构建或测序数据分析经验优先考虑。

聘期待遇以发展前景：

1）聘期2年，可延长至4年；

2）总年薪约27万人民币， 其中包括深圳市政府每年生活补助12万元（免税，限前两年），工资8000元/月，13薪，住房补贴2800元/月，另有17840元/年的福利费（餐补，高温补贴，过节费和计生奖）。除此以外，学校承担五险一金20160元/年和支付公积金11520元/年。

*条件优秀的申请人可以入选校长卓越奖励计划，月工资按13800元发放（合计35万年薪）。

3）学校为每位博士后提供每两年2.5万元的学术交流资助。

个人简介：

翟继先05年本科毕业于中国科学技术大学，08年在中科院遗传与发育生物学研究所曹晓风院士指导下获得遗传学硕士，13年在Blake Meyers教授指导下获得美国特拉华大学博士学位（同期还完成了生物信息和统计学的两个硕士），之后加入加州大学洛杉矶分校美国科学院院士Steve Jacobsen课题组从事博士后研究。16年加入南方科技大学生物系。目前已经在主流期刊上发表了46篇文章，其中第一作者（或共一）8篇，包括Cell, PNAS, Genes&Development, The Plant Cell, PLoS Genetics等顶尖期刊。

代表文章：

At SUSTech

1. Kuo HY, Jacobsen E, Long Y, Chen X, Zhai J# (2017) Characteristics and processing of Pol IV transcripts in Arabidopsis. Journal of Genetics and Genomics in press. (#corresponding author)
2. Nan GL, Zhai J, Arikit S, Morrow D, Fernandes J, Mai L, Nguyen N, Meyers BC, Walbot V (2016), a master basic helix-loop-helix factor, regulates the specification and development of tapetum in maize Development dev.140673
3. Ausin I, Feng S, Yu C, Liu W, Kuo HY, Jacobsen EL, Zhai J, Gallego-Bartolome J, Wang L, Egertsdotter U, Street NR, Jacobsen SE, Wang H (2016) DNA methylome of the 20-gigabase Norway spruce genome. PNAS 113(50):E8106-13

At previous institutions

First author research papers:

4. Zhai J*, Bischof S*, Wang H, Feng S, Lee T, Teng C, Chen X, Park SY, Liu L, Gallego-Bartolome J, Liu W, Henderson I, Meyers BC, Ausin I, Jacobsen SE (2015) A ‘One precursor, One siRNA’ model for Pol IV-dependent siRNA Biogenesis. Cell 163, 445–455 (*co-first author)
5. Zhai J*, Zhang H*, Arikit S, Huang K, Nan G, Walbot V, Meyers BC (2015) Spatiotemporal and cell-type dependent phasiRNA biogenesis in maize male reproduction. PNAS 112(10): 3146-51 (*co-first author)
6. Zhai J, Zhao Y, Simon SA, Huang S, Petsch K, Arikit S, Pillay L, Ji L, et al. (2013) Plant microRNAs display differential 3’-truncation and tailing, modifications which are ARGONAUTE1-dependent and conserved across species. The Plant Cell 25(7):2417-28
7. Zhai J, Jeong D-H, Paoli ED, Park S, Rosen BD, Li Y, González AJ, Yan Z, et al. (2011) MicroRNAs as master regulators of the plant NB-LRR defense gene family via the production of phased, trans-acting siRNAs. Genes & Development 25(23):2540-53.
8. Zhai J, Liu J, Liu B, Li P, Meyers BC, Chen X, Cao X. (2008) Small RNA-directed epigenetic natural variation in Arabidopsis thaliana. PLoS Genetics 4, e1000056.
9. Song X*, Li P*, Zhai J*, Zhou M, Ma L, Liu B, Jeong DH, Cao S, Cui X et al. (2011) Roles of DCL4 and DCL3b in rice phased small RNA biogenesis. The Plant Journal 69, 462-474. (*co-first author)
10. Zhai J, Arikit S, Simon SA, Kingham B, Meyers BC (2013) Construction of Parallel Analysis of RNA End (PARE) Library for Illumina Hi-Seq sequencing. Methods S1046-2023(13)00237-5
11. Zhai J and Meyers BC (2013). Deep Sequencing from hen1 Mutants to Identify Small RNA 3' Modifications. Cold Spring Harb Symp Quant Biol 1943-4456

Co-authored papers (in reverse-chronological order):

12. Yu Y, Ji L, Le B, Zhai J, Chen J, Luscher E, Gao L, Liu C, Cao X, Mo B, Ma J, Meyers BC, Chen X (2017) ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biology, in press.
13. Groth M, Moissiard G, Wirtz M, Wang H, GarciaSalinas G, Ramos-Parra PA, Bischof S, Feng S, Cokus SJ, John A, Smith DC, Zhai J, Hale CJ, Long JA, Hell R, Garza RID, Jacobsen SE (2016) MTHFD1 controls DNA methylation in Arabidopsis. Nature Communication 2016 Jun 13;7:11640
14. Wang H, Beyene G, Zhai J, Feng S, Fahlgren N, Taylor N, Bart R, Carrington JC, Jacobsen SE, Ausin I (2015) CG gene body DNA methylation changes and evolution of duplicated genes in cassava. PNAS 112(44):13729-34
15. Yan Z, Hossain MS, Valdés-López O, Hoang NT, Zhai J, Wang J, Libault M, Joshi T, Brechenmacher L, Findley S, Qiu L, Sherrier DJ, Meyers BC, Xu D, Stacey G (2015) Identification and functional characterization of soybean root hair microRNAs expressed in response to Bradyrhizobium japonicum infection. Plant Biotechnology Journal 10.1111/pbi.12387
16. Tu B, Xu C, Liu L, Zhai J, Li S, Lopez MA, Zhao Y, Yu Y, Ren G, Yu B, Li S, Meyers BC, Mo B, Chen X (2015) Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis. PLoS Genetics 11(4): e1005119
17. Yan Z, Hossain MS, Arikit S, Valdé O, Zhai J, Wang J, Libault M, Ji T, Qiu L, Meyers BC, Stacey G (2015) Identification of MicroRNAs and their mRNA targets during soybean nodule development: Functional analysis of the role of miR393* in soybean nodulation. New Phytologist 10.1111/nph.13365
18. Zhao M, Cai C, Zhai J, Lin F, Li L, Shreve J, Thimmapuram J, Hughes TJ, Meyers BC, Ma J (2015) Coordination of MicroRNAs, PhasiRNAs, and NB-LRR Genes in Immune Responses: Insights from Analyses of Soybean Rps Gene Near-Isogenic Lines. The Plant Genome 10.3835
19. Cantó-Pastor A, Mollá-Morales A, Ernst E, Dahl W, Zhai J, Yan Y, Meyers BC, Shanklin J, Martienssen RA (2015) Efficient transformation and artificial miRNA gene silencing in Lemna minor. Plant Biology 10.1111/plb.12215
20. Arikit S, Xia R, Kakrana A, Huang K, Zhai J, Yan Z, Valdés-López O, Prince S, Musket TA, Nguyen HT, Stacey G, Meyers BC (2014) An atlas of soybean small RNAs demonstrates regulation by phased siRNAs of hundreds of coding genes. The Plant Cell 26: 4584-4601
21. Feng S, Cokus SJ, Schubert V, Zhai J, Pellegrini M, Jacobsen SE (2014) Genome-wide Hi-C analyses in wild type and mutants reveal high-resolution chromatin interactions in Arabidopsis. Molecular Cell 55(5):694-707
22. Wong J, Gao L, Yang Y, Zhai J, Arikit S, Yu Y, Duan S, Xiong Q, Yan J, Li S, Liu R, Wang Y, Tang G, Meyers BC, Chen X, Ma W (2014) Roles of Small RNAs in Soybean Defense against Phytophthora sojae Infection. The Plant Journal 10.1111/tpj.12590
23. Creasey KM, Zhai J, Borges F, Van EF, Meyers BC, Martienssen RA (2014) miRNAs trigger widespread epigenetically-activated siRNAs from transposons in Arabidopsis. Nature 508 (7496):411-5
24. Wei L, Gu L, Song X, Cui X, Lua Z, Zhou M, Wang L, Hu F, Zhai J, Meyers BC, Cao X (2014) Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice. PNAS 111(10):3877-82
25. Schapire A, Bologna NG, Moro B, Zhai J, Meyers BC, Palatnik JF (2013) Construction of Specific Parallel Amplification of RNA Ends (SPARE) libraries for the systematic identification of plant microRNA processing intermediates. Methods doi:10.1016/j.ymeth.2013.08.032
26. Jeong DH, Schmidt SA, Rymarquis LA, Park S, Ganssmann M, German MA, Accerbi M, Zhai J, Paoli ED, Fahlgren N, Fox SE, Garvin DF, Mockler TC, Carrington JC, Meyers BC, and Green PJ (2013) Parallel Analysis of RNA Ends enhances global investigation of microRNAs and target RNAs of Brachypodium distachyon. Genome Biology 14(12):R145
27. Amborella Genome Project. (2013) The Amborella Genome and the Evolution of Flowering Plants. Science 342(6165):1241089
28. Jeong DH, Thatcher SR, Brown RS, Zhai J, Park S, Meyers BC, Green PJ (2013) Comprehensive investigation of miRNAs enhanced by analysis of sequence variants, expression patterns, AGO loading and target cleavage. Plant Physiology 162(3):1225
29. Raman V, Simon SA, Romag A, Demirci F, Mathioni SM, Zhai J, Meyers BC, Donofrio NM (2013) Physiological stressors and invasive plant infections alter the small RNA transcriptome of the rice blast fungus Magnaporthe oryzae. BMC Genomics 14:326
30. Bologna NG, Schapire AL, Zhai J, Chorostecki U, Boisbouvier J, Meyers BC, Palatnik J (2013) Multiple RNA recognition patterns during microRNA biogenesis in plants. Genome Research (10):1675-89
31. Arikit S, Zhai J, Meyers BC (2013) Biogenesis and function of rice small RNAs from non-coding RNA precursors. Current Opinion in Plant Biology 16(2):170-9.
32. Lee TF, Gurazada SG, Zhai J, Li S, Simon SA, Matzke MA, Chen X, Meyers BC (2012) RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. Epigenetics 7(7):781-95
33. Zhao Y, Yu Y, Zhai J, Ramachandran V, Dinh T, Meyers BC, Mo B, Chen X (2012) HESO1, a nucleotidyl transferase in Arabidopsis, uridylates unmethylated miRNAs and siRNAs to trigger their degradation. Current Biology 22(8):689-94
34. The_International_Medicago_Initiative (2011) The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature 480, 520-524
35. Jeong D-H, Park S, Zhai J, Gurazada SGR, Paoli ED, Meyers BC, Green PJ. (2011) Massive analysis of rice small RNAs: Mechanistic implications of regulated miRNAs and variants for differential target RNA cleavage. The Plant Cell 23(12):4185-207.
36. Yu B, Bi L, Zhai J, Agarwal M, Li S, Wu Q, Ding SW, Meyers BC, Vaucheret H, Chen X. (2010) siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis. Nucleic Acids Research 38(17):5844-5850.
37. The International Brachypodium Initiative. (2010) Genome sequencing and analysis of the model grass Brachypodium distachyon. Nature 463(7282):763-768.
38. Meyers BC, Simon SA, Zhai J. (2010) MicroRNA processing: battle of the bulge. Current Biology 20(2):R68-70. (review)
39. Lee TF, Zhai J, Meyers BC. (2010) Conservation and divergence in eukaryotic DNA methylation. PNAS 107(20):9027-9028. (review)
40. Simon SA, Zhai J, Nandety RS, McCormick KP, Zeng J, Mejia D, Meyers BC. (2009) Short-read sequencing technologies for transcriptional analyses. Annual Review Plant Biology 60:305-333. (review)
41. Park W, Zhai J, Lee JY. (2009) Highly efficient gene silencing using perfect complementary artificial miRNA targeting AP1 or heteromeric artificial miRNA targeting AP1 and CAL genes. Plant Cell Rep 28(3):469-480.
42. De Paoli E, Dorantes-Acosta A, Zhai J, Accerbi M, Jeong DH, Park S, Meyers BC, Jorgensen RA, Green PJ. (2009) Distinct extremely abundant siRNAs associated with cosuppression in petunia. RNA 15(11):1965-1970.
43. Simon SA, Zhai J, Zeng J, Meyers BC. (2008) The cornucopia of small RNAs in plant genomes. Rice 1(1):52-62. (review)
44. Pei Y, Niu L, Lu F, Liu C, Zhai J, Kong X, Cao X. (2007) Mutations in the Type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis. Plant Physiology 144, 1913-1923.
45. Ding Y, Wang X, Su L, Zhai J, Cao S, Zhang D, Liu C, Bi Y, Qian Q, Cheng Z, et al. (2007) SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. The Plant Cell 19, 9-22.
46. Xia R, Wang J, Liu C, Wang Y, Zhai J, Liu J, Hong X, Cao X, Zhu JK, Gong Z. (2006) ROR1/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis. The Plant Cell 18, 85-103. 1(1):52-62.

重大脑血管疾病诸如脑卒中的治疗、康复仍缺乏有效的手段，是临床医学上亟待解决的重大问题。我们团队的研究总目标将围绕开发新的、更接近临床情况的复合型动物模型来探讨脑卒中神经细胞损伤后死亡，以及结构和功能恢复的分子机制。 通过结合神经生物学，分子生物学， 药理学等手段，尤其是我们研究组率先发展的的质谱成像代谢组学技术开展脑卒中脂组学研究，以期揭示崭新的神经元损伤信号转导通路以及炎症调控突触可塑性的分子机制， 为开发神经保护制剂和药物提供理论和实践依据。

招聘岗位：

博士后（Postdoctoral Fellow）

岗位要求：

1）认同南科大理念，对科学研究有热情，有上进心和独立开展科研工作的能力，有团队合作精神，恪守科研道德；

2）具有神经生物学博士学历；

3）精通细胞生物学，分子生物学或者神经生物学，尤其是动物神经生理的研究流程；

4）具有较好的英语听说读写能力，在国际期刊上发表过至少一篇英文论文； 

5）具有电生理技术、动物模型制备经验，海外学习经历者优先。

岗位待遇：

参照《南方科技大学博士后管理办法》及深圳市相关条例。

• 薪酬福利不少于22万元（含市财政给予的生活补助12万元/年），其它待遇参考正式教职工执行；特别优秀者可申请校长卓越博士后，薪酬福利可达30万元；
• 出站后自主择业留深工作的，可申请共计10万元的科研资助；
• 符合条件的能够申请深圳政府高层次人才、孔雀人才等相关政策待遇。

申请材料：

• 详细的个人简历，含学习、工作和科研的经历（附近照），主要科研成果（如论文论著、成果证书或奖励）清单；
• 2-3名推荐人的联系方式及推荐信；
• 其他可以证明工作能力的材料。

联系方式：应聘者将个人简历发送到hou.st@sustc.edu.cn

研究助理(实验员)（Research Assistant）

岗位要求：

1）对神经生物学方向的研究工作有强烈兴趣，具有生物学专业背景；

2）掌握动物细胞、神经细胞培养或神经疾病系统模型技术；

3）生物领域相关专业硕士或学士学历；

4）能独立阅读英文文献和撰写英文文章；

5）有哺乳动物细胞培养经验者优先。

岗位待遇：

• 薪资面议，提供住宿和五险一金。
• 有很大的机会就读本校硕博研究生，到世界一流科研院所交流访问。

申请材料：

1）详细的个人简历，含学习、工作和科研的经历（附近照），主要科研成果（如论文论著、成果证书或奖励）清单；

2）其他可以证明工作能力的材料。

联系方式：应聘者将个人简历发送到hou.st@sustc.edu.cn

课题组简介：南方科技大学生物系欧西军课题组诚聘博士后研究人员2名，本课题组主要通过分子生物学、生物化学和细胞生物学的方法，利用小鼠模型来研究B淋巴细胞的发育和功能，以及体液免疫应答调控的分子机制。课题组详细信息请见https://bio.sustech.edu.cn/?p=213

岗位描述与职责：独立完成课题研究，发表高水平学术论文。协助课题组长指导低年级研究生的训练与培养。

岗位要求：生命科学或者医学相关专业博士毕业（或者即将毕业）；熟练掌握分子生物学、生物化学或者细胞生物学等技术。

待遇：参照《南科大博士后管理办法》及深圳市相关条例，年薪不少于22万元（含市政补贴税后12万元/年），享受正式教职工待遇；优秀者可申请校长卓越博士后，年薪30万/年。符合条件者可申请深圳市政府高层次人才、孔雀人才计划等政策待遇。

联系方式：本课题组刚成立不久，希望营造一种宽松、自由、积极向上的实验室文化，在愉快的环境下去探索未知的免疫学世界。热诚欢迎有志之士加盟，有意者请将详细简历发送至：ouxj@sustc.edu.cn，来信请注明预期到岗时间。本广告长期有效，直到岗位招满为止。

谢宇聪课题组的主要研究有关细胞生物学的生命科学问题。利用秀丽隐杆线虫及人体细胞进行细胞分裂、细胞粘附及迁移的分子机理和与发育生物学相关的研究。近期，我们更开始研究有关化学荧光染料在生物显微成像技术的应用，并已取得不错的进展。因此，拟招聘一名研究助理教授/副教授负责参与细胞分裂、发育生物学或显微成像应用的相关研究。

研究助理/副教授招聘

应聘条件:

• 已经取得生物学、生物化学或分子生物学等相关博士学位；
• 博士毕业后从事科研工作两年或以上；
• 以第一作者发表2篇或以上SCI文章；
• 热爱科研、 具有高度积极性、专业性及团队合作精神。具备独立思考并解决生物学问题的能力；
• 具有良好的英语会话及写作能力。

岗位待遇:

• 提供具竞争性薪金(不少于25万，面议) ；
• 提供一至两名全职科研助理协助课题开展；
• 拥有良好先进的科研条件、浓厚的学术氛围、优质的合作导师；
• 可作为负责人申请国家自然科学基金及省、市各级课题；
• 符合条件的可以申请深圳市孔雀计划人才补助160万或以上。

联系方式：应聘者请将个人简历发送至tseyc@sustc.edu.cn