个人简介：

贾宁，医学院副教授，博士生导师。入选《麻省理工科技评论》“35岁以下科技创新35人”亚太区榜单（2022），美国布拉瓦尼克区域青年科学家化学奖获得者（2020）。2016年于中国科学技术大学生命学院获得博士学位， 随后在美国纪念斯隆凯特琳癌症中心从事博士后研究。2021年5月加入南方科技大学医学院。长期聚焦于细菌抗噬菌体免疫机制研究，近年来以通讯作者身份发表论文15篇 (Science 2025a, 2025b；Nature Chemical Biology 2024；Molecular Cell 2023，2019a, 2019b, 2019c；Nature Communications, 2024a,b, 2022; Nature Reviews Molecular Cell Biology, 2021； Cell Research, 2024, 2022, 2020;等)。其中，Nature Communications, 2022 被世界学术组织“Faculty Opinions (原F1000Prime)”推荐；担任Nature、Science、Nature Microbiology、Nature Catalysis、Nature Chemical Biology等杂志审稿人。加入Journal of Biological Chemistry (JBC)、mLife期刊作为Editorial Board member。主持国自然面上、省市基金多项。

教育背景：

2006-2010 中国海洋大学， 海洋生物资源与环境，学士

2010-2016 中国科学技术大学，生物化学与分子生物学，博士 （导师周丛照、陈宇星教授）

工作经历：

2022.06-至今  南方科技大学医学院，副教授

2021.05-2022.05 南方科技大学医学院，助理教授

2017-2021 美国纪念斯隆凯特琳癌症中心，博士后 （导师：Dinshaw J. Patel）

获奖情况及荣誉：

2024     入选Journal of Biological Chemistry (JBC)和mLife期刊的Editorial Board member

2022     入选《麻省理工科技评论》“35岁以下科技创新35人”亚太区榜单（2022）

2021     深圳海外高层次人才（孔雀B类）

2020      美国布拉瓦尼克区域青年科学家化学奖 (2020 Blavatnik Regional Awards for Young Scientists Winner in Chemistry)

2016      蔡司-斑马鱼科学研究奖

2010       山东省优秀毕业生

2007，2009 国家奖学金

研究兴趣：

1）课题组通过结合生物化学、分子生物学、微生物学及结构生物学等手段，探究微生物与宿主免疫系统相互作用的分子机制，尤其关注细菌和古菌免疫防御系统（如CRISPR-Cas适应性免疫系统）抵御噬菌体侵染的分子机制。

2）基于微生物与宿主免疫系统相互作用分子机制的理解，开发相应的生物技术工具（如CRISPR-Cas基因编辑工具）。

学术任职：

Journal of Biological Chemistry (JBC)、mLife期刊的Editorial Board member

纽约科学学会（The New York Academy of Sciences）会员 

发表论文：

（#第一作者;   *通讯作者 ）

1. Song, X. Y.#; Xia, Y.#; Zhang, J. T.#; Liu, Y. J.; Qi, H.; Wei, X. Y.; Hu, H.;Xia, Y.; Liu, X.; Ma, Y.F.; Jia, N.* (2025). Bacterial reverse transcriptase synthesizes long polyA-rich cDNA for anti-phage defense, Science, 2025 May 1:eads4639. doi: 10.1126/science.ads4639.

2. Hayes, V. M. #; Zhang, J. T.#; Katz, M. A.; Li, Y.; Kocsis, B.; Jia, N.*; Meeske, A. J.* (2025). RNA-mediated CRISPR-Cas13 inhibition via crRNA structural mimicry. Science, 388(6745): 387-391

3. Zhang, J.T.; Wei, X.Y.; Cui, N.; Tian, R. & Jia, N. * (2024). Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nature Chemical Biology 20, 503-511 .

4. Cui, N.#; Zhang, J.T.#; Li, Z.; Wei, X.Y.; Wang, J. and Jia, N.* (2024). Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system. Nature Communications 15, 8610 .

5. Zhang, J.T.#; Liu, X. Y.#; Li, Z.#;Wei, X.Y.; Song, X.Y.; Cui, N.; Zhong, J.; Li, H.; Jia, N.* (2024). Structure and genome editing activity of the novel CRISPR-Cas12o1 effector.  Cell research. 10.1038/s41422-024-01050-y.

6. Zhang, J.T.#; Liu, X.Y.#; Li, Z.L.#; Wei, X.Y.; Song, X.Y.; Cui, N.; Zhong, J.; Li, H. and Jia, N.* (2024). Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system. Nature Communications 15, 2797.

7. Cui, N.#; Zhang, J.T.#; Li, Y.; Liu, Y.; Liu, X.Y.; Wang, C.; Huang, H.* and Jia, N.* (2023). Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment. Molecular Cell 83, 2493-2508 e2495.

8. Duan, Z.#; Zhang, X.#; Zhang, J.T.; Li, S; Liu, R.; Sun, J.; Zhao, Q.; Jia, N.; Jia, N.* and Zhu, J.K.* (2023). Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05. Cell Discovery 9, 117. 10.1038/s41421-023-00612-5.

9. Cui, N.#; Zhang, J.T.#; Li, Z.; Liu, X.Y.;Wang, C.; Huang, H.* and Jia, N.* (2022). Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nature Communications 13, 7549. 

10. Patel, D.J.*; Yu, Y. and Jia, N. (2022). Bacterial origins of cyclic nucleotide-activated antiviral immune signaling. Molecular Cell 82, 4591-4610.  

11. Jia, N.* & Patel, D.J.* (2022). Structure-based evolutionary relationship between IscB and Cas9. Cell Research 32, 875-877. 

12. Jia, N.*; Patel. D. J.* (2021). Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins. Nature reviews. Molecular Cell Biology 22, 563-579, doi:10.1038/s41580-021-00371-9.

13. Meeske A. J.#; Jia, N.#; Cassel A.K.; Kozlova A.; Liao J.; Wiedmann M.; Patel D. J.*; Marraffini L. A.* (2020). A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Science 369, 54-59.

14. Jia, N.*; Xie, W.; De La Cruz, J.M.; Eng, E.T.; Patel, D.J.* (2020). Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Research 30, 182-184.

15. Jia, N.*; Jones, R.; Yang, G.; Ouerfelli, O.; Patel, D.J.* (2019). CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity. Molecular Cell 75, 944-956 e946.

16. Jia, N.*; Jones, R.; Sukenick, G.; Patel, D.J.* (2019). Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Molecular Cell 75, 933-943 e936. 

17. Jia, N.*; Mo, C.Y.;Wang, C.; Eng, E.T.; Marraffini, L.A.; Patel, D.J.* (2019). Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Molecular Cell 73, 264-277 e265. 

18. Jia, N.#; Unciuleac, M.#; Xue C.; Greene E.C.; Patel, D.J.*; Shuman, S.* (2019). Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America 116, 24507-24516. 

19. Jia, N.; Liu, N.; Cheng, W.; Jiang, Y.L.; Sun, H.; Chen, L.L.; Peng, J.; Zhang, Y.; Ding, Y.H.; Zhang, Z.H.; et al. (2016). Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO reports 17, 235-248.

20. Chen, L.L.; Xie, J.; Cao, D.D.; Jia, N.; Li, Y.J.; Sun, H.; Li, W.F.; Hu, B.; Chen, Y.; Zhou, C.Z. (2018). The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection. Dev Comp Immunol 82, 49-54.

21. Zhou, K.; Jia, N.; Hu, C.; Jiang, Y.L.; Yang, J.P.; Chen, Y.; Li, S.; Li, W.F.; Zhou, C.Z. (2014). Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins 82, 3224-3229. 

22. Song, N.; Jia, N.; Yanagimoto, T.; Lin, L.; Gao, T. (2013). Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region. Mitochondrial DNA 24, 705-712.

23. He, Y.X.; Zhang, N.N.; Li, W.F.; Jia, N.; Chen, B.Y.; Zhou, K.; Zhang, J.; Chen, Y.; Zhou, C.Z. (2012). N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease. Journal of molecular biology 418, 197-207.